Cation channel sperm-associated protein subunit delta/epsilon (IPR028751)

Short name: CATSPERD/E

Overlapping homologous superfamilies


Family relationships



CATSPER (cationic channel of sperm) is a complex ion channel that mediates Ca2+ entry in sperm flagellum and is required for sperm hyperactivation and male fertility [PMID: 11595941]. The CATSPER channel consists of four CatSper proteins (CatSper1-4) that form a tetramer surrounding a Ca(2+)-selective pore. In addition to the pore-forming proteins, the CATSPER channel contains auxiliary subunits, including CatSperD (cation channel sperm-associated protein subunit delta) [PMID: 21224844] and CatSperE. CatSperD is essential for the cation channel function and may play a role in channel assembly or transport.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0036128 CatSper complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.