A-kinase anchor protein 9/Pericentrin (IPR028745)

Short name: AKAP9/Pericentrin

Overlapping homologous superfamilies


Family relationships



A-kinase anchor protein 9 (AKAP9, also known as AKAP 350) and pericentrin (pericentrin-B, kendrin) are large coiled-coil proteins found in mammalian centrosomes that serve to recruit structural and regulatory components including dynein and protein kinase [PMID: 10545494, PMID: 15047863]. These scaffold proteins contain a pericentrin-AKAP-450 centrosomal targeting (PACT) domain [PMID: 11263498].

Mutations of AKAP9 cause long QT syndrome 11 (LQT11), which is a heart disorder characterised by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias [PMID: 18093912]. AKAP9 has also been implicated in breast cancer [PMID: 21931171] and sporadic papillary thyroid carcinomas [PMID: 16753739]. In mice, AKAP9 is essential for Spermatogenesis and sertoli cell maturation [PMID: 23608191].

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0032947 protein-containing complex scaffold activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.