Serine/threonine-protein kinase LATS1 (IPR028741)

Short name: LATS1

Overlapping homologous superfamilies


Family relationships



There are two mammalian homologue of Drosophila tumor suppressor Lats (large tumor suppressor, also known as Warts): LATS1 and LATS2. Lats/Warts is a serine/threonine-protein kinase that negatively regulates YAP1 (Drosophila Yorkie (Yki) homologue) in the Hippo signaling pathway, which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis [PMID: 18158288, PMID: 16096061].

This entry represents LATS1 from mammals. During cell division, LATS1 interacts with MOB1A and serves as a mitotic exit network kinase [PMID: 16061636].

GO terms

Biological Process

GO:0035329 hippo signaling
GO:0000278 mitotic cell cycle

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.