LIM domain and actin-binding protein 1 (IPR028740)

Short name: EPLIN

Overlapping homologous superfamilies


Family relationships



LIM domain and actin-binding protein 1 (LIMA1, also know as EPLIN) is a cytoskeleton-associated protein that regulates actin dynamics by cross-linking and stabilising filaments [PMID: 12566430]. It was first identified as the product of a gene that is transcriptionally down-regulated or lost in a number of human epithelial tumor cells [PMID: 10618726, PMID: 9591775]. In humans, there are two EPLIN isoforms, EPLIN alpha and EPLIN beta, both have a centrally located LIM domain that may mediate self-dimerisation. EPLIN inhibits Arp2/3 complex-mediated branching nucleation of actin filaments and stabilises actin filament networks [PMID: 12566430]. EPLIN can be regulated through phophoryltion by extracellular signal-regulated kinase (ERK) [PMID: 17875928].

GO terms

Biological Process

GO:0051017 actin filament bundle assembly
GO:0030835 negative regulation of actin filament depolymerization

Molecular Function

GO:0051015 actin filament binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.