LIM domain-containing protein 1 (IPR028734)

Short name: LIMD1

Overlapping homologous superfamilies


Family relationships



LIM domain-containing protein 1 (LIMD1) is an adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organisation, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration [PMID: 15542589, PMID: 20303269, PMID: 20616046]. LIMD1 is a critical tumor suppressor involved in human lung cancer development [PMID: 19060205], and reduced expression has also been demonstrated in breast and head and neck squamous cell carcinomas [PMID: 20226061, PMID: 18439753]. LIMD1 binds the retinoblastoma protein (pRB) and acts as a co-repressor of E2F-driven transcription [PMID: 15542589].

GO terms

Biological Process

GO:0045892 negative regulation of transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.