Sperm-associated antigen 5 (IPR028728)

Short name: Astrin

Overlapping homologous superfamilies


Family relationships



Sperm-associated antigen 5 (Spag5, also known as astrin) is an essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase [PMID: 11724960]. It is part of the astrin (SPAG5)-kinastrin (SKAP) complex that promotes stable microtubule-kinetochore attachments [PMID: 21402792]. Targeting Astrin to the centrosome during the S and G2 phases requires another protein, Ninein [PMID: 17383637]. Postmitotically, astrin interacts with USH proteins and may function together in microtubule-based cytoplasmic trafficking of proteins that are essential for cilium formation, maintenance and/or function [PMID: 23351521].

GO terms

Biological Process

GO:0051301 cell division
GO:0051988 regulation of attachment of spindle microtubules to kinetochore

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.