Chromodomain-helicase-DNA-binding protein 4 (IPR028725)

Short name: CHD4

Overlapping homologous superfamilies


Family relationships



There are nine members of the Chromodomain, Helicase, DNA-binding (CHD) family. They are characterised by two chromodomains arranged in tandem, N-terminal to the ATPase/helicase domain. Chromodomains are comprised of a beta-sheet folded against an alpha-helix that collectively mediates binding to methyl-lysine residues [PMID: 23954449].

This entry represents chromodomain-helicase-DNA-binding protein 4 (CHD4), also known as Mi2-beta. CHD4 and CHD3 belong to the class II subfamily of CHD ATPases, and each is present as a core catalytic subunit in separate NuRD complexes, which regulate chromatin organisation and gene transcription [PMID: 23340908]. CHD4 is also a RanGTP-dependent microtubule (MT)-associated protein that stabilises microtubules and regulates bipolar spindle formation [PMID: 24268414].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0042826 histone deacetylase binding

Cellular Component

GO:0016581 NuRD complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.