Chromodomain-helicase-DNA-binding protein 3 (IPR028722)

Short name: CHD3

Overlapping homologous superfamilies


Family relationships



There are nine members of the Chromodomain, Helicase, DNA-binding (CHD) family. They are characterised by two chromodomains arranged in tandem, N-terminal to the ATPase/helicase domain. Chromodomains are comprised of a beta-sheet folded against an alpha-helix that collectively mediates binding to methyl-lysine residues [PMID: 23954449].

This entry represents chromodomain-helicase-DNA-binding protein 3 (CHD3, also known as Mi-2alpha). CHD3 and CHD4 belong to the class II subfamily of CHD ATPases, and each is present as a core catalytic subunit in separate NuRD complexes, which regulate chromatin organisation and gene transcription [PMID: 23340908]. CHD3 is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organisation and centrosome integrity [PMID: 17626165].

GO terms

Biological Process

GO:0007098 centrosome cycle
GO:0006325 chromatin organization
GO:0007051 spindle organization

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016581 NuRD complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.