Macrophage metalloelastase (IPR028718)

Short name: MMP12

Overlapping homologous superfamilies


Family relationships


Macrophage metalloelastase (also known as matrix metalloproteinase-12, MMP12) was first identified as a secreted protein from mouse peritoneal macrophages through its elastase activity [PMID: 167096]. It shares many features with typical members of the matrix metalloproteinase (MMP) family including its domain structure and its ability to degrade the extracellular matrix components [PMID: 23813962]. MMP12 regulates fibrosis in several models of tissue injury and has a protective effect on corneal fibrosis during wound repair through regulation of immune cell infiltration and angiogenesis [PMID: 23813962].

GO terms

Biological Process

GO:0006508 proteolysis
GO:0042060 wound healing

Molecular Function

GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.