Vesicle-associated membrane protein 2 (IPR028717)

Short name: VAMP2

Overlapping homologous superfamilies


Family relationships


Vesicle-associated membrane protein 2 (VAMP2, also known as Synaptobrevin-2) belongs to the VAMP family, which is a group of small, integral membrane proteins of synaptic vesicles that is mostly involved in vesicle fusion. Neurotransmitter release involves the assembly of a heterotrimeric SNARE complex composed of SNAP25, VAMP2 and syntaxin 1 [PMID: 12145198]. VAMP2 plays a specific role in the insulin-dependent recruitment of GLUT4 from its intracellular storage compartment to the cell surface [PMID: 9430681].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.