Collagenase 3 (IPR028711)

Short name: Collagenase_3

Overlapping homologous superfamilies

Family relationships


Matrix metalloproteinases (MMPs) are zinc-dependent and calcium-dependent proteases that degrade most components of the extracellular matrix (ECM) and process a number of bioactive molecules. Collagenases are MMPs that share the ability to cleave the native helix of fibrillar collagens at a single peptide bond. There are several collagenases: interstitial collagenase (MMP-1 or collagenase-1), neutrophil collagenase (MMP-8 or collagenase-2), collagenase-3 (MMP-13) and Xenopus collagenase-4 (MM18). This entry represents collagenases 3 and 4.

Collagenase-3 (MMP-13) degrades collagen type I, II and III [PMID: 20196103]. It is highly overexpressed in human carcinomas and osteoarthritis [PMID: 10949577, PMID: 2329846, PMID: 19787229].

GO terms

Biological Process

GO:0030574 collagen catabolic process
GO:0006508 proteolysis

Molecular Function

GO:0004222 metalloendopeptidase activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.