Stromelysin-3 (IPR028705)

Short name: Stromelysin-3

Overlapping homologous superfamilies


Family relationships


Matrix metalloproteinases (MMPs) are zinc-dependent and calcium-dependent proteases that degrade most components of the extracellular matrix (ECM) and process a number of bioactive molecules.

Stromelysin-3 (also known as MMP11) may play an important role in the progression of epithelial malignancies [PMID: 1701851]. It is expressed in tissues undergoing the active remodelling associated with embryonic development, wound healing and tumour invasion. Stromelysin-3 is activated by furin, a Golgi-associated proteinase [PMID: 7746327].

GO terms

Biological Process

GO:0007275 multicellular organism development
GO:0006508 proteolysis

Molecular Function

GO:0004222 metalloendopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.