Stromelysin 1 (IPR028700)

Short name: Stromelysin_1

Family relationships


Matrix metalloproteinases (MMPs) degrade most components of the extracellular matrix (ECM) and process a number of bioactive molecules. This entry represents stromelysin-1.

Stromelysin-1 (also known as MMP3) has a rather broad substrate specificity: it can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Besides degrading multiple ECM proteins, it can also activate growth factors, cleave cell adhesion molecules, chemokines, cytokines and various receptors. Stromelysin-1 is considered to play a central role in the activation of various proMMPs, including proMMP-1 (interstitial procollagenase), proMMP-7 and proMMP-9 (neutrophil procollagenase) [PMID: 9578462]. It can contribute to several pathologies, such as cancer, asthma and rheumatoid arthritis [PMID: 22862420].

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004222 metalloendopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.