Synaptotagmin-11 (IPR028699)

Short name: SYT11

Overlapping homologous superfamilies

Family relationships



Synaptotagmin-11 (SYT11) belongs to the synaptotagmin family, which is a group of membrane-trafficking proteins that contain two C-terminal C2 domains (known as C2A and C2B domains). Most of the synaptotagmins have a unique N-terminal domain (transmembrane region) that is involved in membrane anchoring or specific ligand binding.

The SYT11 gene is located on a major susceptibility locus of familial schizophrenia [PMID: 17192956]. The STY11 loci has also been linked to Parkinson's disease (PD) [PMID: 23153929]. Parkin, a ubiquitin ligase, binds to the C2A and C2B domains of SYT11 resulting in the polyubiquitination of SYT11 [PMID: 12925569].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.