Synaptotagmin-14 (IPR028696)

Short name: SYT14

Overlapping homologous superfamilies


Family relationships



Synaptotagmin-14 (SYT14) belongs to the synaptotagmin family, which is a group of membrane-trafficking proteins that contain two C-terminal C2 domains (known as C2A and C2B domains). Most of the synaptotagmins have a unique N-terminal domain (transmembrane region) that is involved in membrane anchoring or specific ligand binding.

In mammals, SYT14 is expressed in brain (especially in the cerebellum) [PMID: 21835308]. Mutations in SYT14 gene cause spinocerebellar ataxia, autosomal recessive, 11 (SCAR11), which is a clinically and genetically heterogeneous group of cerebellar disorders [PMID: 21835308].

This entry also includes synaptotagmin-14-like protein (SYT14L, also known as sytdep) from human, which is highly expressed in mature peripheral blood neutrophils [PMID: 16376304].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.