Matrix metalloproteinase-14 (IPR028693)

Short name: MMP14

Overlapping homologous superfamilies

Family relationships


Matrix metalloproteinases (MMPs) are zinc-dependent and calcium-dependent proteases that cleave within a polypeptide (endopeptidases). They degrade most components of the extracellular matrix (such as growth factors, their binding proteins, and other bioactive molecules, as well as binding sites for cell-surface molecules) and some non-extracellular-matrix molecules [PMID: 12801404]. Two categories of MMPs can be recognised based on their cellular localisation: soluble vs. membrane-bound. The soluble MMPs are divided into the collagenases (MMP1, MMP8 and MMP13), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP12) and those yet to be classified. The membrane-bound MMPs include MT1, 2, 3, 4, 5 and their hallmark is the presence of plasma membrane anchoring domains [PMID: 12027585]. MMPs are highly expressed in various cancers, both by tumour cells and in surrounding stromal cells such as macrophages [PMID: 12801404].

Matrix metalloproteinase-14 (MMP14), also known as membrane-type matrix metalloproteinase 1 (MT-MMP1), seems to specifically activate progelatinase A (MMP2) [PMID: 8663332]. The activated gelatinase A is crucial for remodelling processes and is thought to be involved in tumour invasion and metastasis. Thus MMP14 may trigger invasion by tumour cells by activating progelatinase A on the tumour cell surface [PMID: 8015608, PMID: 22065321].

MMP14 has a important function in connective tissue metabolism. Modelling of the soft connective tissue matrix by resident cells is essential for the development and maintenance of the hard tissues of the skeleton [PMID: 10520996]. MMP14 cleaves PTK7, defective receptor protein tyrosine kinase that plays an important role in migration, invasion of endothelial cells and angiogenesis [PMID: 20837484, PMID: 21518755].

GO terms

Biological Process

GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0006508 proteolysis

Molecular Function

GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.