Syntaxin-17 (IPR028676)

Short name: STX17

Overlapping homologous superfamilies

Family relationships



Syntaxin-17 (STX17) belongs to the syntaxin family, which is a group of the membrane integrated proteins participating in exocytosis. Syntaxins are associated with various intracellular membrane compartments and have been implicated in various physiological processes such as axonal growth and cell division [PMID: 18691641].

STX17 is required to maintain the architecture of ER-Golgi intermediate compartment and Golgi [PMID: 21545355]. STX17 is also involved in the fusion of autophagosomes with endosomes/lysosomes. Its unique C-terminal hairpin structure mediated by two tandem transmembrane domains is essential for its association with the autophagosomal membrane [PMID: 23217709].

GO terms

Biological Process

GO:0006888 ER to Golgi vesicle-mediated transport
GO:0097352 autophagosome maturation
GO:0097111 endoplasmic reticulum-Golgi intermediate compartment organization

Molecular Function

GO:0000149 SNARE binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.