Lipid phosphate phosphohydrolase 2 (IPR028674)

Short name: LPP2

Overlapping homologous superfamilies

Family relationships



Type 2 lipid phosphate phosphohydrolases (LPPs), formerly known as phosphatidic acid phosphatases (PAPs), are enzymes that catalyse the hydrolysis of a variety of lipid phosphate mono-esters, including lysophosphatidic acid (LPA), PA, diacylglycerolpyrophosphate, S1P and ceramide 1-phosphate (C-1-P). These are lipid mediators that exert complex effects on cell function through actions at cell surface receptors and on intracellular targets [PMID: 12069809]. Type 2 LPPs are membrane bound enzymes, Mg2+-independent and N-ethylmaleimide-insensitive [PMID: 17079146]. In humans, at least three genes coding for type 2 LPP enzymes have been identified (LPP1, LPP2 and LPP3).

This entry represents LPP2, also known as PPAP2C [PMID: 9607309]. PPAP2C is overexpressed in several cancers. In cancer cells, PPAP2C is involved in S-phase progression and is regulated by p53 [PMID: 19139135].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008195 phosphatidate phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.