Lipid phosphate phosphohydrolase 1 (IPR028670)

Short name: LPP1

Overlapping homologous superfamilies

Family relationships



Type 2 lipid phosphate phosphohydrolases (LPPs), formerly known as phosphatidic acid phosphatases (PAPs), are enzymes that catalyse the hydrolysis of a variety of lipid phosphate mono-esters, including lysophosphatidic acid (LPA), PA, diacylglycerolpyrophosphate, S1P and ceramide 1-phosphate (C-1-P). These are lipid mediators that exert complex effects on cell function through actions at cell surface receptors and on intracellular targets [PMID: 12069809]. Type 2 LPPs are membrane bound enzymes, Mg2+-independent and N-ethylmaleimide-insensitive [PMID: 17079146]. In humans, at least three genes coding for type 2 LPP enzymes have been identified (LPP1, LPP2 and LPP3).

LPP1, also known as PPAP2A, exhibits a preference for glycerol-versus sphingoid base-containing lipids [PMID: 10620492]. LPP1 plays a physiological role in controlling the degradation of circulating lysophosphatidic acid (LPA) [PMID: 19215222], a lipid mediator that stimulates cell proliferation and growth, and is involved in physiological and pathological processes such as wound healing, platelet activation, angiogenesis and the growth of tumours. LPP1 regulates LPA production and signaling in platelets [PMID: 12909631].

GO terms

Biological Process

GO:0006629 lipid metabolic process

Molecular Function

GO:0008195 phosphatidate phosphatase activity

Cellular Component

GO:0005886 plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.