Family

Syntaxin 1 (IPR028669)

Short name: STX1A/1B

Family relationships

None.

Description

Syntaxin 1 (STX1) contains two isoforms, syntaxins 1A and 1B (STX1A/STX1B). They belong to the syntaxin family, which is a group of the membrane integrated proteins participating in exocytosis. Syntaxins are associated with various intracellular membrane compartments and have been implicated in various physiological processes such as axonal growth and cell division [PMID: 18691641]. Syntaxins possess a SNARE domain which binds to both synaptobrevin and SNAP-25 forming the core SNARE complex [PMID: 9759724]. The formation of the SNARE complex is the key step that leads to vesicle fusion.

STX1 plays an important role in ion channel regulation and synaptic exocytosis. The binding of Munc18-1 with closed form of STX1 hinders formation of SNARE complexes [PMID: 21900493, PMID: 12093152]. STX1 may also mediates Ca2+-regulation of exocytosis acrosomal reaction in sperm [PMID: 15774481].

In humans, STX1B encodes two alternatively spliced isoforms, one of which lacks the classical C-terminal transmembrane domain and localises to the nuclei [PMID: 18691641].

GO terms

Biological Process

GO:0017157 regulation of exocytosis
GO:0016192 vesicle-mediated transport

Molecular Function

GO:0000149 SNARE binding

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
PANTHER