Sorting nexin-17 (IPR028666)

Short name: SNX17

Overlapping homologous superfamilies


Family relationships


Sorting nexin-17 (SNX17) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that may be responsible for binding to specific phosphoinositides [PMID: 16243015]. SNX17 also possess an additional FERM-like domain [PMID: 21512128].

SNX17 is a critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. It binds to Asn-Pro-Xaa-Tyr (NPxY) sequences in the cytoplasmic tails of cargo such as LDL receptors and the amyloid precursor protein [PMID: 21512128].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.