Sorting nexin-5 (IPR028654)

Short name: SNX5

Overlapping homologous superfamilies

Family relationships


Sorting nexin-5 (SNX5) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that is responsible for binding to specific phosphoinositides [PMID: 16243015]. SNX5 also contains a BAR domain that is C terminus to the PX domain. Besides being involved in several stages of intracellular trafficking, SNX5 also plays a role in macropinocytosis and in the internalisation of EGFR after EGF stimulation [PMID: 18854019, PMID: 21048941].

GO terms

Biological Process

GO:0006886 intracellular protein transport
GO:0006907 pinocytosis

Molecular Function

GO:0035091 phosphatidylinositol binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.