Inhibitor of growth protein 4 (IPR028647)

Short name: ING4

Overlapping homologous superfamilies


Family relationships

  • ING family (IPR028651)
    • Inhibitor of growth protein 4 (IPR028647)


Members of the ING (inhibitor of growth protein) family of tumour suppressors regulate cell cycle progression, apoptosis, and DNA repair as important cofactors of p53 [PMID: 16387653, PMID: 12750254]. Inhibitor of growth protein 4 (ING4) is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo [PMID: 16387653]. ING4 binds to histone H3 trimethylated at Lys-4 (H3K4me3) through its C-terminal plant homeodomain, thus recruiting the HBO1 histone acetyltransferase complex to target promoters [PMID: 18381289, PMID: 22334692]. It may inhibit tumour progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation [PMID: 19187765].

GO terms

Biological Process

GO:0016573 histone acetylation
GO:0008285 negative regulation of cell population proliferation
GO:0043065 positive regulation of apoptotic process

Molecular Function

GO:0035064 methylated histone binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.