Inhibitor of growth protein 4 (IPR028647)

Short name: ING4

Overlapping homologous superfamilies


Family relationships



Members of the ING (inhibitor of growth protein) family of tumour suppressors regulate cell cycle progression, apoptosis, and DNA repair as important cofactors of p53 [PMID: 16387653, PMID: 12750254]. Inhibitor of growth protein 4 (ING4) is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo [PMID: 16387653]. ING4 binds to histone H3 trimethylated at Lys-4 (H3K4me3) through its C-terminal plant homeodomain, thus recruiting the HBO1 histone acetyltransferase complex to target promoters [PMID: 18381289, PMID: 22334692]. It may inhibit tumour progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation [PMID: 19187765].

GO terms

Biological Process

GO:0016573 histone acetylation
GO:0008285 negative regulation of cell proliferation
GO:0043065 positive regulation of apoptotic process

Molecular Function

GO:0035064 methylated histone binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.