Inhibitor of growth protein 2 (IPR028639)

Short name: ING2

Overlapping homologous superfamilies


Family relationships



Members of the ING (inhibitor of growth protein) family of tumour suppressors regulate cell cycle progression, senescence, apoptosis, and DNA repair as important cofactors of p53. Inhibitor of growth protein 2 (ING2) seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53 [PMID: 11481424]. It is also a component of a chromatin-modifying complex containing the transcriptional co-repressor SIN3A and HDAC1 (histone deacetylase 1), which is involved in deacetylation of nucleosomal histones [PMID: 16387653, PMID: 20676127]. The stability of ING2 is regulated by nuclear phosphatidylinositol-5-phosphate at discrete chromatin targets in response to DNA damage [PMID: 12859901, PMID: 23823870].

GO terms

Biological Process

GO:0006325 chromatin organization
GO:0008285 negative regulation of cell proliferation
GO:0042981 regulation of apoptotic process
GO:2000772 regulation of cellular senescence

Molecular Function

GO:0003682 chromatin binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.