Inhibitor of growth protein 5 (IPR028638)

Short name: ING5

Family relationships

  • ING family (IPR028651)
    • Inhibitor of growth protein 5 (IPR028638)


Members of the ING (Inhibitor of growth protein) family of tumour suppressors regulate cell cycle progression, apoptosis, and DNA repair as important cofactors of p53. Inhibitor of growth protein 5 (ING5) is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. It is also a component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation ING5 may regulate DNA replication and function as a transcriptional coactivator [PMID: 12750254, PMID: 16387653, PMID: 21750715].

GO terms

Biological Process

GO:0016573 histone acetylation
GO:0008285 negative regulation of cell proliferation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0070776 MOZ/MORF histone acetyltransferase complex
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.