Family

Inhibitor of growth protein 5 (IPR028638)

Short name: ING5

Family relationships

None.

Description

Members of the ING (Inhibitor of growth protein) family of tumour suppressors regulate cell cycle progression, apoptosis, and DNA repair as important cofactors of p53. Inhibitor of growth protein 5 (ING5) is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. It is also a component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation ING5 may regulate DNA replication and function as a transcriptional coactivator [PMID: 12750254, PMID: 16387653, PMID: 21750715].

GO terms

Biological Process

GO:0016573 histone acetylation
GO:0008285 negative regulation of cell proliferation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0070776 MOZ/MORF histone acetyltransferase complex
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER