Clavesin-2 (IPR028636)

Short name: Clavesin-2

Overlapping homologous superfamilies

Family relationships



Clavesin 1 and 2 (clathrin vesicle-associated Sec14 protein) are neuron-specific proteins that function in the regulation of endosome/lysosome morphology [PMID: 19651769]. The Sec14 domain (also known as the CRAL-TRIO domain) from clavesin binds phosphatidylinositol 3,5-bisphosphate.

This entry represents clavesin-2.

GO terms

Biological Process

GO:0007040 lysosome organization

Molecular Function

GO:0080025 phosphatidylinositol-3,5-bisphosphate binding

Cellular Component

GO:0030136 clathrin-coated vesicle
GO:0005768 endosome
GO:0005802 trans-Golgi network

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.