ATP-dependent RNA helicase RhlE (IPR028622)

Short name: DEAD_helicase_RhlE

Overlapping homologous superfamilies

Family relationships



RNA helicases from the DEAD-box family are found in almost all organisms and have important roles in RNA metabolism, such as splicing, RNA transport, ribosome biogenesis, translation and RNA decay. They are enzymes that unwind double-stranded RNA molecules in an energy dependent fashion through the hydrolysis of NTP. DEAD-box RNA helicases belong to superfamily 2 (SF2) of helicases. As other SF1 and SF2 members they contain seven conserved motifs which are characteristic of these two superfamilies [PMID: 1531961]. DEAD-box is named after the amino acids of motif II or Walker B (Mg2+-binding aspartic acid).

RhlE is a DEAD-box RNA helicase that is involved in ribosome assembly. It may play a role in the interconversion of ribosomal RNA-folding intermediates that are further processed by DeaD or SrmB during ribosome maturation [PMID: 18083833].

GO terms

Biological Process

GO:0042255 ribosome assembly

Molecular Function

GO:0004004 ATP-dependent RNA helicase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.