ATP-dependent RNA helicase DbpA (IPR028619)

Short name: DEAD_helicase_DbpA

Overlapping homologous superfamilies

Family relationships



RNA helicases from the DEAD-box family are found in almost all organisms and have important roles in RNA metabolism, such as splicing, RNA transport, ribosome biogenesis, translation and RNA decay. They are enzymes that unwind double-stranded RNA molecules in an energy dependent fashion through the hydrolysis of NTP. DEAD-box RNA helicases belong to superfamily 2 (SF2) of helicases. As other SF1 and SF2 members they contain seven conserved motifs which are characteristic of these two superfamilies [PMID: 1531961]. DEAD-box is named after the amino acids of motif II or Walker B (Mg2+-binding aspartic acid).

The RNA helicase DbpA has an RNA-dependent ATPase activity, which is specific for 23S rRNA [PMID: 8253085, PMID: 9016593]. It is involved in assembly of the 50S ribosomal subunit [PMID: 19734347].

GO terms

Biological Process

GO:0000027 ribosomal large subunit assembly

Molecular Function

GO:0003724 RNA helicase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.