ATP-dependent RNA helicase DeaD (IPR028618)

Short name: DEAD_helicase_DeaD

Overlapping homologous superfamilies

Family relationships



RNA helicases from the DEAD-box family are found in almost all organisms and have important roles in RNA metabolism, such as splicing, RNA transport, ribosome biogenesis, translation and RNA decay. They are enzymes that unwind double-stranded RNA molecules in an energy dependent fashion through the hydrolysis of NTP. DEAD-box RNA helicases belong to superfamily 2 (SF2) of helicases. As other SF1 and SF2 members they contain seven conserved motifs which are characteristic of these two superfamilies [PMID: 1531961]. DEAD-box is named after the amino acids of motif II or Walker B (Mg2+-binding aspartic acid).

The RNA helicase DeaD is ATP-dependent [PMID: 2045359] and is induced by low temperatures [PMID: 8552679]. In addition to its role in unwinding double stranded RNA, it is involved in ribosomal subunit biogenesis [PMID: 15148362].

GO terms

Biological Process

GO:0070417 cellular response to cold
GO:0000027 ribosomal large subunit assembly

Molecular Function

GO:0004004 ATP-dependent RNA helicase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.