Probable cytosolic iron-sulfur protein assembly protein, CIAO1/Cia1 (IPR028608)

Short name: CIAO1/Cia1

Overlapping homologous superfamilies


Family relationships



Proteins in this entry are probable cytosolic iron-sulfur (FeS) protein assembly proteins from eucaryotes, including Cia1 from Saccharomyces cerevisiae and CIAO1 from humans. Iron-sulfur [Fe-S] clusters are ubiquitous and evolutionary ancient prosthetic groups that are required to sustain fundamental life processes [PMID: 15952888]. They can be used as part of catalytic centres for chemical sensing, stabilise protein structure and determine protein function [PMID: 20522543].

In Saccharomyces cerevisiae, Cia1 is a component of cytosolic iron-sulfur cluster assembly (CIA) system (consists of Nar1, Nbp35 and Cia1). It is involved in a late step of Fe/S cluster incorporation into target proteins [PMID: 16314508].

In humans, it is also a component of the human CIA system. Moreover, it binds to IOP1 and forms the MMXD complex (MMS19, XPD, MIP18 and ANT2), which is involved in chromosome segregation [PMID: 23585563, PMID: 20797633].

GO terms

Biological Process

GO:0016226 iron-sulfur cluster assembly

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0097361 CIA complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.