RISC-loading complex subunit TRBP2 (IPR028605)

Short name: TRBP2

Overlapping homologous superfamilies


Family relationships



TRBP2 was first identified as a HIV-1 TAR RNA-binding protein [PMID: 2011739]. TRBP2 is a component of the RISC loading complex (RLC), which functions in RNA-mediated gene silencing (RNAi). It is a double-stranded RNA (dsRNA)-binding protein that associates with endonuclease Dicer, which cleaves precursor RNA molecules to produce microRNAs (miRNAs) and short interfering RNAs (siRNAs) in RNAi pathway [PMID: 23661684]. Together with another dsRNA-binding protein, PACT, they function as key regulators of miRNA and siRNA biogenesis by Dicer in substrate recognition, binding, processing and RISC loading [PMID: 23661684].

GO terms

Biological Process

GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0031054 pre-miRNA processing
GO:0030422 production of siRNA involved in RNA interference
GO:0046782 regulation of viral transcription

Molecular Function

GO:0003725 double-stranded RNA binding
GO:0035197 siRNA binding

Cellular Component

GO:0016442 RISC complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.