Protein argonaute-3 (IPR028603)

Short name: AGO3

Overlapping homologous superfamilies


Family relationships



Argonaute proteins are involved in RNA interference (RNAi) and microRNA (miRNA) pathways. They can be classified into three paralogous groups: Argonaute-like proteins, which are similar to Arabidopsis thaliana AGO1; Piwi-like proteins, which are closely related to D. melanogaster PIWI (P-element induced wimpy testis); and the Caenorhabditis elegans-specific group 3 Argonautes [PMID: 18073770].

Protein argonaute-3 (AGO3) belongs to the first group (Argonaute-like proteins) [PMID: 18073770]. It lacks endonuclease activity and does not appear to cleave target mRNAs [PMID: 23064648]. During human stem cells proliferation, AGO3 is involved in accumulation of processed DR2 Alu transcripts and subsequent recruitment of AGO3-associated decapping complexes to the target mRNA [PMID: 23064648].

GO terms

Biological Process

GO:0031047 gene silencing by RNA
GO:0072091 regulation of stem cell proliferation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.