Leucine zipper putative tumour suppressor 2 (IPR028597)

Short name: LZTS2

Overlapping homologous superfamilies


Family relationships



Leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1) interacts with p80 katanin and regulates katanin-mediated microtubule severing [PMID: 18490357]. It is localised to the centrosome and the midbody in mitotic cells. During prophase, LAPSER1/LZTS2 inhibits centrosomal gamma-tubulin accumulation, which results in retardation of mitotic entry. During interphase, LAPSER1/LZTS2 inhibits katanin, which results in prevention of cell motility [PMID: 18490357]. LAPSER1/LZTS2 also modulates beta-catenin signaling and localisation [PMID: 17000760].

LAPSER1/LZTS2 has been identified as a candidate tumor suppressor gene in prostate cancer [PMID: 17351128].

GO terms

Biological Process

GO:0051301 cell division

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.