Katanin p60 subunit A1 (IPR028596)

Short name: KATNA1

Overlapping homologous superfamilies

Family relationships


Katanin is an ATP-dependent microtubule severing protein composed of 60 kDa (katanin-p60) and 80 kDa (katanin-p80) subunits encoded by KATNA1 and KATNB1 genes, respectively [PMID: 23894477]. Katanin-p60 has the enzymatic activity for microtubule severing, while katanin-p80 possesses multiple functions such as targeting katanin-p60 to the centrosome, augmenting microtubule severing by katanin-p60, and even suppressing microtubule severing [PMID: 23894477].

This entry represents the katanin p60 subunit A1 subfamily, including KATNA1 and KATNAL1 from humans, and meiotic spindle formation protein MEI-1 from C. elegans. MEI-1 is required for translocation of the meiosis I spindle to the oocyte cortex in C. elegans [PMID: 12885567].

GO terms

Biological Process

GO:0051013 microtubule severing

Molecular Function

GO:0008017 microtubule binding
GO:0008568 microtubule-severing ATPase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.