AdoMet-dependent rRNA methyltransferase, Spb1 (IPR028589)

Short name: Spb1

Overlapping homologous superfamilies


Family relationships


Spb1 is an adoMet-dependent rRNA methyltransferase required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit [PMID: 10556316]. In Saccharomyces cerevisiae, it specifically methylates the guanosine in position 2922 of the 25S rRNA at the stage of 27S pre-rRNA maturation [PMID: 15546625]. It interacts with the snoRNA-associated proteins Nop1 and Nop58 [PMID: 10648622].

FTSJ3, Spb1 homologue in humans, is associates with NIP7 (involved in the biogenesis of 40S subunit) and functions in pre-rRNA processing [PMID: 22195017].

GO terms

Biological Process

GO:0031167 rRNA methylation

Molecular Function

GO:0008649 rRNA methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.