Adenylate kinase 2 (IPR028587)

Short name: AK2

Overlapping homologous superfamilies

Family relationships


This entry represents the adenylate kinase 2 (AK2) subfamily of the adenylate kinases (AKs), which are nucleoside monophosphate kinases that catalyse the phosphorylation of AMP by using ATP or GTP as phosphate donors. Proteins in this entry include AK2 from humans, Adk1 from budding yeasts.

In humans, nine different AK isoenzymes have been identified (AK1-9). AK2 is the major mitochondrial isoform and is expressed in the mitochondrial intermembrane space of tissues rich in mitochondria such as liver, heart and skeletal muscle [PMID: 23416111]. Mutations in AK2 gene cause the reticular dysgenesis (aleukocytosis), which is the most severe form of inborn severe combined immunodeficiencies [PMID: 19043417].

In budding yeasts, Adk1 (also known as Aky2) is the major isoform of AKs. It is found in both cytoplasm and mitochondrial intermembrane space. It has no cleavable mitochondrial targeting sequence [PMID: 12045196].

GO terms

Biological Process

GO:0006172 ADP biosynthetic process

Molecular Function

GO:0004017 adenylate kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.