Transcription factor Maf (IPR028573)
Short name: Maf/V-MAF
Overlapping homologous superfamilies
- Transcription factor Maf family (IPR024874)
- Transcription factor Maf (IPR028573)
Maf transcription factors form a distinct subfamily of the basic leucine zipper (bZip) transcription factors [PMID: 17569705]. Maf genes have been identified in a wide range of higher eukaryotes, including both vertebrate and invertebrate species. These proteins are unique among the bZip factors in that they contain a highly conserved extended homology region (EHR), or ancillary DNA binding region, in addition to a typical basic region, and both regions are involved in target DNA sequence recognition. Maf transcription factors regulate tissue-specific gene expression and cell-differentiation in a wide variety of tissues and are also involved in human diseases and oncogenic transformation. Tissue-specific expression invloves Maf binding to Maf-recognition elements (MAREs) in the regulatory regions of target genes, and interacting with other transcription factors.
This entry includes the Maf protein from vertebrates and V-MAF from Avian musculoaponeurotic fibrosarcoma virus AS42 [PMID: 2554284].
- PTHR10129:SF9 (PTHR10129:SF9)