Transcription factor MafB (IPR028571)

Short name: MafB

Overlapping homologous superfamilies


Family relationships


Maf transcription factors form a distinct family of the basic leucine zipper (bZip) transcription factors. The Maf family is divided into two subclasses, large Mafs (c-maf, mafB, and mafA/L-maf, nrl) and small Mafs (MafF, MafK and MafG). Both subclasses contain leucine-zipper motifs, which allow homodimerisation as well as heterodimerisation with a variety of other bZip proteins. In contrast to the small Mafs, the large Maf proteins contain a transactivator domain in their amino terminus.

MafB plays critical roles in a variety of cellular differentiation processes, including in kidney podocytes [PMID: 12217315], macrophages [PMID: 16943423, PMID: 19632180], and pancreatic islet alpha and beta-cells, which are responsible for the production of the hormones glucagon and insulin respectively. MafB is also expressed in alpha-cells in adult pancreas and is important for their function [PMID: 17360442, PMID: 20627934, PMID: 21719305, PMID: 16443760].

Mutations in Maf gene cause multicentric carpotarsal osteolysis syndrome (MCTO), which is a rare skeletal disorder, usually presenting in early childhood with a clinical picture mimicking juvenile rheumatoid arthritis [PMID: 22387013].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA binding transcription factor activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.