Telomere-associated protein Rif1 (IPR028566)

Short name: Rif1

Family relationships



In Saccharomyces cerevisiae Rif1 interacts with Rif2 and Rap1 to regulate telomere length and establish telomeric silencing [PMID: 1577274]. Despite the protein sequence similarity with yeast Rif1, human Rif1 does not bind to Rap1 and does not accumulate at functional telomeres. Human Rif1 is required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint) and is regulated by ATM and 53BP1 [PMID: 15342490].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.