Pathways & interactions
Mu homology domain (IPR028565)
Short name: MHD
Overlapping homologous superfamilies
- AP-2 complex subunit mu, C-terminal superfamily (IPR036168)
- Mu homology domain (IPR028565)
- Muniscin C-terminal (IPR018808)
The mu homology domain (MHD) is an ~280 residue protein-protein interaction module, which is found in endocytotic proteins involved in clathrin-mediated endocytosis [PMID: 11381094, PMID: 11454741, PMID: 14726597, PMID: 19713939]:
- Mu subunits of adaptor protein (AP) complexes, AP-1, AP-2, AP-3, and AP-4.
- Proteins of the stonin family.
- Proteins of the muniscin family: Syp1, FCHO1/2 and SGIP1.
The MHD domain has an elongated, banana-shaped, all beta-sheet structure. It can be considered as two beta-sandwich subdomains (A and B), with subdomain B inserted between strands 6 and 15 of subdomain A, and joined edge to edge such that the convex surface is a continuous nine-stranded mixed beta-sheet that runs the whole length of the molecule. The tyrosine based signal binds to a site on the surface of two parallel beta-sheet strands (beta1 and beta16) in subdomain A [PMID: 19713939, PMID: 9812899].