Transcription factor MafA (IPR028562)

Short name: MafA

Overlapping homologous superfamilies


Family relationships


Maf transcription factors form a distinct family of the basic leucine zipper (bZip) transcription factors. The Maf family is divided into two subclasses, large Mafs (c-maf, mafB, and mafA/L-maf, nrl) and small Mafs (MafF, MafK and MafG). Both subclasses contain leucine-zipper motifs, which allow homodimerisation as well as heterodimerisation with a variety of other bZip proteins. In contrast to the small Mafs, the large Maf proteins contain a transactivator domain in their amino terminus [PMID: 19143053]. The small Maf proteins might contribute to oncogenic processes by participating in antioxidant responses, while large Maf proteins have been directly implicated in carcinogenesis [PMID: 19143053].

This entry represents MafA. MafA plays a critical role in the regulation of crystalline genes and lens development [PMID: 9525857, PMID: 9674710]. It also binds the insulin enhancer element RIPE3b and regulates the insulin gene transcription [PMID: 12011435, PMID: 15923615, PMID: 15665000].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA binding transcription factor activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.