Transcription factor MafG (IPR028551)

Short name: MafG

Family relationships


Maf transcription factors form a distinct family of the basic leucine zipper (bZip) transcription factors [PMID: 22721719]. The Maf family is divided into two subclasses, large Mafs and small Mafs (MafF, MafK [PMID: 8361754] and MafG [PMID: 9166829]). Both subclasses contain leucine-zipper motifs, which allow homodimerisation as well as heterodimerisation with a variety of other bZip proteins. Small Mafs can act as negative regulators of transcription by recruiting transcriptional repressors or by forming homodimers that can then displace active dimers. Small Mafs lack a transactivator domain, but they can also serve as transcriptional activators by dimerising with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites.

This entry represents MafG. The p45/MafG heterodimer plays a role in the regulation of erythropoiesis [PMID: 9166829] and may be involved in signal transduction of extracellular H+ [PMID: 11583919]. MAFG is up-regulated in smokers [PMID: 19168627].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0046982 protein heterodimerization activity
GO:0003700 transcription factor activity, sequence-specific DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.