Short name: Klotho
Overlapping homologous superfamilies
- Glycoside hydrolase superfamily (IPR017853)
- Glycoside hydrolase family 1 (IPR001360)
- Klotho (IPR028546)
Klotho (named after a Greek goddess Klotho who spins the thread of life) was first identified as a gene disrupted in a mouse strain that inherited a syndrome resembling human ageing in an autosomal recessive manner [PMID: 9363890]. Klotho is related to glycoside hydrolase and have two forms, membrane Klotho and secreted Klotho. Membrane Klotho forms a complex with fibroblast growth factor receptors and functions as an co-receptor for fibroblast growth factor 23, while secreted Klotho functions as a humoral factor that regulates activity of multiple glycoproteins on the cell surface [PMID: 19730882]. The secreted Klotho may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signalling [PMID: 16123266]. Overexpression of Klotho in mice can extend life span [PMID: 16123266].
Mutations in human Klotho cause the tumoral calcinosis, hyperphosphatemic, familial (HFTC): a severe metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues [PMID: 17710231].
- PTHR10353:SF10 (PTHR10353:SF10)