Klotho (IPR028546)

Short name: Klotho

Overlapping homologous superfamilies

Family relationships


Klotho (named after a Greek goddess Klotho who spins the thread of life) was first identified as a gene disrupted in a mouse strain that inherited a syndrome resembling human ageing in an autosomal recessive manner [PMID: 9363890]. Klotho is related to glycoside hydrolase and have two forms, membrane Klotho and secreted Klotho. Membrane Klotho forms a complex with fibroblast growth factor receptors and functions as an co-receptor for fibroblast growth factor 23, while secreted Klotho functions as a humoral factor that regulates activity of multiple glycoproteins on the cell surface [PMID: 19730882]. The secreted Klotho may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signalling [PMID: 16123266]. Overexpression of Klotho in mice can extend life span [PMID: 16123266].

Mutations in human Klotho cause the tumoral calcinosis, hyperphosphatemic, familial (HFTC): a severe metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues [PMID: 17710231].

GO terms

Biological Process

GO:0007568 aging
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008286 insulin receptor signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005615 extracellular space
GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.