Protein CASC3 (IPR028544)

Short name: CASC3

Overlapping homologous superfamilies


Family relationships



MLN51 (also known as CASC3) is a component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism [PMID: 17652158]. It stimulates the ATPase and RNA-helicase activities of EIF4A3 [PMID: 17375189]. In humans, it is overexpressed in breast cancer [PMID: 12080473]. The structure of the EJC containing MLN51 has been resolved [PMID: 16931718].

GO terms

Biological Process

GO:0006397 mRNA processing

Molecular Function

GO:0003723 RNA binding

Cellular Component

GO:0035145 exon-exon junction complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.