Tyrosine-protein kinase Fer (IPR028539)
Short name: Fer
Overlapping homologous superfamilies
- Tyrosine-protein kinase, Fes/Fps type (IPR016250)
- Tyrosine-protein kinase Fer (IPR028539)
Fer (EC:126.96.36.199) is a tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis [PMID: 19738202, PMID: 17606629]. In non-small cell lung cancer cells, Fer kinase expression has been linked to cell invasion and tumour metastasis [PMID: 23699534]. It also acts downstream of EGFR (EGF receptor) to promote activation of NF-kappa-B and cell proliferation [PMID: 21518868].
GO:0031532 actin cytoskeleton reorganization
GO:0008283 cell proliferation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0030335 positive regulation of cell migration
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
No terms assigned in this category.
- PTHR24418:SF227 (PTHR24418:SF227)