Tyrosine-protein kinase Fer (IPR028539)

Short name: Fer

Overlapping homologous superfamilies


Family relationships


Fer (EC: is a tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis [PMID: 19738202, PMID: 17606629]. In non-small cell lung cancer cells, Fer kinase expression has been linked to cell invasion and tumour metastasis [PMID: 23699534]. It also acts downstream of EGFR (EGF receptor) to promote activation of NF-kappa-B and cell proliferation [PMID: 21518868].

GO terms

Biological Process

GO:0031532 actin cytoskeleton reorganization
GO:0008283 cell proliferation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0030335 positive regulation of cell migration
GO:0042058 regulation of epidermal growth factor receptor signaling pathway

Molecular Function

GO:0005154 epidermal growth factor receptor binding
GO:0004713 protein tyrosine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.