Chitinase-3-like protein 1 (IPR028538)

Short name: CHI3L1

Overlapping homologous superfamilies

Family relationships



Chitinase-3-like protein (CHI3L1), also known as cartilage glycoprotein 39 (YKL-40), is a carbohydrate-binding lectin with a preference for chitin [PMID: 9492324, PMID: 8245017]. It is a a member of the glycosyl hydrolase 18 family, but lacks hydrolytic activity, probably because of a single amino acid substitution in the catalytic centre region [PMID: 9492324]. Chitinase-3-like protein is implicated in cell proliferation and angiogenesis and has been shown to stimulate migration and adhesion of cultured vascular smooth muscle cells [PMID: 12799184, PMID: 21357475]. It is secreted by various immune, connective tissue and cancer cells and it is associated with inflammatory disorders, like asthma and atopy [PMID: 18403759, PMID: 19568425, PMID: 16234240].

GO terms

Biological Process

GO:0045766 positive regulation of angiogenesis

Molecular Function

GO:0008061 chitin binding

Cellular Component

GO:0005615 extracellular space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.