PDZ and LIM domain protein 1 (IPR028537)

Short name: PDLIM1

Overlapping homologous superfamilies


Family relationships



PDZ and LIM domain protein 1 (PDZ-LIM1, also known as CLP-36) is a member of the PDZ-LIM family of adapter proteins that have been implicated in cytoskeleton organisation, neuronal signalling, cell lineage specification, organ development, and oncogenesis [PMID: 17767364]. Several PDZ-LIM proteins are predominantly expressed in striated muscle. However, CLP36 is expressed in several nonmuscle tissues [PMID: 10753915]. CLP36 binds to alpha-actinin-1 and may direct alpha-actinin-1 to specific actin structures [PMID: 11110697]. CLP36 also recruits the Clik1 kinase to actin stress fibres in nonmuscle cells [PMID: 11973348].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005856 cytoskeleton

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.