Dipeptidase 1 (IPR028536)

Short name: Dpep1

Overlapping homologous superfamilies

Family relationships


Dipeptidase 1 (Dpep1), renal dipeptidase (RDP), or microsomal dipeptidase is a zinc-dependent metalloenzyme that hydrolyses a wide range of dipeptides. It is implicated in the renal metabolism of glutathione and its conjugates. It converts leukotriene D4 to leukotriene E4 and it may play an important role in the regulation of leukotriene activity [PMID: 8054366]. Renal dipeptidase seems to be evolutionary related to hypothetical proteins in the PQQ biosynthesis operons of Acinetobacter calcoaceticus and Klebsiella pneumoniae [PMID: 7674922].

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0016805 dipeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.