Hematopoietic lineage cell-specific protein (IPR028534)

Short name: HS1

Overlapping homologous superfamilies


Family relationships



Hematopoietic lineage cell-specific protein (HS1) is a substrate of antigen receptor-coupled tyrosine kinases and it is expressed only in tissues and cells of hematopoietic origin [PMID: 7682714, PMID: 12534372]. Tyrosine phosphorylation of HS1 is important for regulating lymphocyte trafficking [PMID: 20530793], neutrophil chemotaxis [PMID: 22679023] and growth arrest and apoptosis [PMID: 8088319]. HS1 is able to bind to F-actin and can increase the rate of actin assembly mediated by the Arp2/3 complex [PMID: 12534372, PMID: 16157603].

GO terms

Biological Process

GO:0030041 actin filament polymerization

Molecular Function

GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.