Formin-binding protein 1 (IPR028532)

Short name: FNBP1/FBP17

Family relationships



Formin-binding protein 1 (FNBP1, also known as formin-binding protein 17) contains a N-terminal FER-CIP4 homology (FCH) domain and a C-terminal SH3 domain. It belongs to the CIP4 (Cdc42 interacting protein-4) subfamily of the F-BAR (F for FCH, Fer-CIP4 homology domain) protein family. The F-BAR proteins have been implicated in cell membrane processes such as membrane invagination, tubulation and endocytosis [PMID: 23384583]. FNBP1 was originally isolated as a molecule that binds to the proline-rich region of formin [PMID: 8605874]. It induces tubular membrane invaginations and participates in endocytosis [PMID: 15252009]. It interacts with sorting nexin, SNX2 and is linked to acute myelogeneous leukemia [PMID: 11438682].

GO terms

Biological Process

GO:0006897 endocytosis

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.